So, I am happy to mention this news article.
A drone pilot's nightmare came true when operators lost control of an armed MQ-9 Reaper flying a combat mission over Afghanistan on Sunday. That led a manned U.S. aircraft to shoot down the unresponsive drone before it flew beyond the edge of Afghanistan airspace.Regards — Cliff
The U.S. Air Force stated that a manned aircraft took "proactive measures" to shoot down the Reaper, which ended up crashing into the side of a mountain. Reaper drones have typically engaged in hunter-killer missions over Iraq, Afghanistan and Pakistan by targeting enemies on the ground with Hellfire missiles.